CareLit · DOI-Nachweis · Zeitschrift für Orthopädie und Unfallchirurgie
Molecular Profiling of Liver Sinusoidal Endothelial Cells in Comparison to Hepatocytes: Reflection on Which Cell Type Should Be the Target for Gene Therapy
DOI 10.1055/a-1282-2286
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Autor:innenOsman El-Maarri, Muhammad Ahmer Jamil, Johannes Oldenburg
ZeitschriftZeitschrift für Orthopädie und Unfallchirurgie
Ausgabe11/2020
Jahrgang / SeitenJg. 40 · S. S26-S31
Kernaussage aus der Literatur
Abstract-Vorschau
AbstractHuman factor VIII (FVIII), which deficiency leads to hemophilia A, is largely synthesized and secreted by the liver sinusoidal endothelial cells (LSECs). However, the characteristics of these cells that secrete FVIII are not well known. We have previously reported that based on genome-wide expression and CpG methylation profiling, LSECs have a distinct molecular profile that distinguishes them from other end…
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Zitierempfehlung
Osman El-Maarri, Muhammad Ahmer Jamil, Johannes Oldenburg (2020) Molecular Profiling of Liver Sinusoidal Endothelial Cells in Comparison to Hepatocytes: Reflection on Which Cell Type Should Be the Target for Gene Therapy. Zeitschrift für Orthopädie und Unfallchirurgie, 40 (11), S26-S31. https://doi.org/10.1055/a-1282-2286
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