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Increased off-target binding of [18F]florbetaben in the skull of women with reduced skull density

Noah Hipp, Kim Lea Young, Ivayla Ilieva Apostolova, Susanne Klutmann, Iris Hardewig, Norman Koglin, Jürgen Gallinat, Ralph Buchert · Nuklearmedizin - NuclearMedicine · Ausgabe 04/2024 · S. 247-251

DOI 10.1055/a-2246-5292

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Autor:innenNoah Hipp, Kim Lea Young, Ivayla Ilieva Apostolova, Susanne Klutmann, Iris Hardewig, Norman Koglin, Jürgen Gallinat, Ralph Buchert
ZeitschriftNuklearmedizin - NuclearMedicine
Ausgabe04/2024
Jahrgang / SeitenJg. 63 · S. 247-251

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Abstract-Vorschau

Abstract Aim To investigate the relationship between off-target binding of the amyloid tracer [18F]florbetaben (FBB) in the skull and skull density. Methods Forty-three consecutive patients were included retrospectively (age 70.2±7.5y, 42% females, 65% amyloid-positive). For each patient, CT skull density (in Hounsfield units) and (late) FBB uptake in the skull were obtained using an individual skull mask generated…

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Noah Hipp, Kim Lea Young, Ivayla Ilieva Apostolova, Susanne Klutmann, Iris Hardewig, Norman Koglin, Jürgen Gallinat, Ralph Buchert (2024) Increased off-target binding of [18F]florbetaben in the skull of women with reduced skull density. Nuklearmedizin - NuclearMedicine, 63 (04), 247-251. https://doi.org/10.1055/a-2246-5292

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