CareLit · DOI-Nachweis · Aktuelle Neurologie
Detrimental effect of minocycline on mitochondrial function induced by increased permeability to small solutes
DOI 10.1055/s-0028-1086536
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Siemen, K Kupsch, S Hertel, P Kreutzmann, G Wolf, C.W Wallesch, P Schönfeld
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Minocyclin (MC) had been considered a neuroprotectant possibly by inhibiting the permeability transition pore of the inner mitochondrial membrane (Zhu, 2002, Nature 417, 74). Doubts on this view, however, were raised when a multicentre, randomised placebo-controlled phase III trial with ALS patients recently showed that MC has harmful effects. This observation has implications for treatment of patients with other ne…
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Zitierempfehlung
D Siemen, K Kupsch, S Hertel, P Kreutzmann, G Wolf, C.W Wallesch, P Schönfeld (2008) Detrimental effect of minocycline on mitochondrial function induced by increased permeability to small solutes. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086536
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