CareLit · DOI-Nachweis · Aktuelle Neurologie
Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells
DOI 10.1055/s-0028-1086601
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Koch, K Lehmann-Horn, J.C Dächsel, T Gasser, P.J Kahle, C.B Lücking
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Mutations in the gene encoding the E3 ubiquitin-protein ligase parkin have been shown to be a common genetic cause of familial early-onset Parkinson's disease (PD). In addition to its function in the ubiquitin-proteasome system (UPS), parkin has been ascribed general neuroprotective properties. Stress and mutation induced decreases in parkin solubility leading to compromised cytoprotection have recently been reporte…
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Zitierempfehlung
A Koch, K Lehmann-Horn, J.C Dächsel, T Gasser, P.J Kahle, C.B Lücking (2008) Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086601
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