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Properties of iron-induced alpha-synuclein oligomers determined on a single particle level

J Levin, T Högen, K Bötzel, M Kostka, H Kretzschmar, A Giese · Aktuelle Neurologie · Ausgabe 09/2008

DOI 10.1055/s-0028-1086604

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Autor:innenJ Levin, T Högen, K Bötzel, M Kostka, H Kretzschmar, A Giese
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Formation of fibrillar protein aggregates is a key event in several neurodegenerative diseases including Parkinson's disease, which is characterized by Lewy bodies and degeneration of dopaminergic neurons. Several lines of evidence implicate involvement of alpha-synuclein oligomers as the principal toxic aggregate species as well as iron ions in the disease progression in Parkinson's disease. Using three independent…

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J Levin, T Högen, K Bötzel, M Kostka, H Kretzschmar, A Giese (2008) Properties of iron-induced alpha-synuclein oligomers determined on a single particle level. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086604

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