CareLit · DOI-Nachweis · Aktuelle Neurologie
The involvement of the GGA protein family in BACE transport and APP processing in Alzheimer's disease
DOI 10.1055/s-0028-1086621
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Nachweis in CareLit
Autor:innenC Steinmetz, B von Einem, D Schwanzar, F Dolp, A.C Ludolph, A Rück, C.A.F von Arnim
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Abeta plaques are one of the pathological hallmarks in Alzheimer's disease (AD). Abeta generation is caused by sequential cleavage of the amyloid precursor protein (APP). Beta-site of APP-cleaving enzyme (BACE) is known to cleave APP followed by Gamma-secretase. The resulting Abeta accumulates in extracellular senile plaques and is associated with further neuron degeneration. APP and BACE traffic toget…
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Zitierempfehlung
C Steinmetz, B von Einem, D Schwanzar, F Dolp, A.C Ludolph, A Rück, C.A.F von Arnim (2008) The involvement of the GGA protein family in BACE transport and APP processing in Alzheimer's disease. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086621
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