CareLit · DOI-Nachweis · Aktuelle Neurologie
Reduced mRNA and protein expression of the transcriptional co-activator PGC-1alpha in post-mortem tissue of ALS patients and in the G93A transgenic ALS mouse model
DOI 10.1055/s-0028-1086658
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Sarlette, K Krampfl, N von Neuhoff, R Dengler, S Petri
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disorder with an average survival of 3–5 years after the onset of symptoms. It is characterized by a rapidly progressive paralysis due to the degeneration of motor neurons in primary motor cortex, brain stem and spinal cord. About 90% of cases occur sporadically and 10% are familial. Among the familial cases, 10–20% can be attributed to…
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Zitierempfehlung
A Sarlette, K Krampfl, N von Neuhoff, R Dengler, S Petri (2008) Reduced mRNA and protein expression of the transcriptional co-activator PGC-1alpha in post-mortem tissue of ALS patients and in the G93A transgenic ALS mouse model. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086658
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