CareLit · DOI-Nachweis · Aktuelle Neurologie
ZK200775, ZK187638, ZK238519 and ZK166350: comparison of different potent antagonists of AMPA-type glutamate receptor channels and their potential role for neuroprotection
DOI 10.1055/s-0028-1086659
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Borngräber, F Schlesinger, S Petri, R Dengler, K Krampfl
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Neurodegeneration in several diseases like amyotrophic lateral sclerosis is at least in part caused by chronic excitotoxicity. AMPA-receptor-mediated fast excitatory synaptic transmission induces an increase of the intracellular calcium-concentration, that might explain one pathway in the pathophysiological model of chronical excitotoxicity. Therefore, neuroprotection by antagonising AMPA-receptor mediated synaptic…
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Zitierempfehlung
M Borngräber, F Schlesinger, S Petri, R Dengler, K Krampfl (2008) ZK200775, ZK187638, ZK238519 and ZK166350: comparison of different potent antagonists of AMPA-type glutamate receptor channels and their potential role for neuroprotection. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086659
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