CareLit · DOI-Nachweis · Aktuelle Neurologie
tPA and MMP-9 interactions in focal cerebral ischaemia: distinct mechanisms of gene regulation
DOI 10.1055/s-0028-1086715
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Lee, P Zickler, S Jander
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objectives: Tissue plaminogen activator (tPA) is broadly used for thrombolysis in acute ischaemic stroke, but recent data suggest additional pleiotropic actions including cytokine-like features and activation of matrixmetalloproteinases (MMP). tPA augments MMP-9 activity thereby leading to neurovascular proteolysis, infarct enlargement, and hemorrhage. On the other hand MMP-9 may also promote beneficial tissue repai…
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Zitierempfehlung
J Lee, P Zickler, S Jander (2008) tPA and MMP-9 interactions in focal cerebral ischaemia: distinct mechanisms of gene regulation. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086715
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