CareLit · DOI-Nachweis · Aktuelle Neurologie
CXCR3 promotes cerebellar inflammation but prevents ocular destruction in transgenic mice with a TH1-driven neuroinflammation
DOI 10.1055/s-0028-1086722
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Krauthausen, S Carter, M Sarris, D Wakefield, M.T Heneka, I.L Campbell, M Müller
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
CXCR3 and its ligands are important for the trafficking of activated TH1 T-cells during inflammation. Recent functional studies demonstrate a more diverse role of CXCR3 in inflammatory CNS diseases. In EAE, the animal model for MS, CXCR3 does not promote the influx of encephalitogenic T cells into the brain but restricts the invasion of effector T cells into the parenchyma, thereby exerting a protective effect. Howe…
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Zitierempfehlung
M Krauthausen, S Carter, M Sarris, D Wakefield, M.T Heneka, I.L Campbell, M Müller (2008) CXCR3 promotes cerebellar inflammation but prevents ocular destruction in transgenic mice with a TH1-driven neuroinflammation. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086722
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