CareLit · DOI-Nachweis · Aktuelle Neurologie
Norepinephrine induces a samaritan phenotype of microglia in an Alzheimer disease mouse model
DOI 10.1055/s-0028-1086724
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Nachweis in CareLit
Autor:innenM.T Heneka, L Dumitrescu-Ozimek, D Terwel, M Clermont-Timmer, L Tatenhorst, J Walter, M.P Kummer
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Loss of locus ceruleus (LC) neurons, degeneration of noradrenergic projections and decrease of norepinephrine (NE) in projection areas represent an early feature of Alzheimer's disease (AD). To elucidate the effect of NE loss on AD pathology, we evaluated NE effects on microglial functions including cytokine generation, migration and phagocytosis in vitro and in vivo. NE stimulation abolished amyloid beta (Aß) induc…
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Zitierempfehlung
M.T Heneka, L Dumitrescu-Ozimek, D Terwel, M Clermont-Timmer, L Tatenhorst, J Walter, M.P Kummer (2008) Norepinephrine induces a samaritan phenotype of microglia in an Alzheimer disease mouse model. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086724
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