CareLit · DOI-Nachweis · Aktuelle Neurologie
Spontaneous aggregation of CADASIL-mutated Notch3
DOI 10.1055/s-0028-1086825
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Nachweis in CareLit
Autor:innenC Opherk, M Düring, N Peters, B Bader, A Giese, M Dichgans
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Mutations in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary small vessel disease leading to recurrent stroke and vascular dementia. Disease-causing mutations invariably affect cysteine residues within epidermal growth factor (EGF)-like repeat domains in the extracellular domain of the Notch3 (N3) receptor. A centr…
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Zitierempfehlung
C Opherk, M Düring, N Peters, B Bader, A Giese, M Dichgans (2008) Spontaneous aggregation of CADASIL-mutated Notch3. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086825
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