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Expression and regulation of the two cyclooxygenase isoforms in rhesus macaque brain during lentivirus infection: differentiation of reversible inflammatory and irreversible neuronal sequelae

C Depboylu, M Bette, D Rausch, E Weihe, L.E Eiden · Aktuelle Neurologie · Ausgabe 09/2008

DOI 10.1055/s-0028-1086901

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Autor:innenC Depboylu, M Bette, D Rausch, E Weihe, L.E Eiden
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

The regulation of cyclooxygenase type-1 and type-2 (COX-1, COX-2), key enzymes in the conversion of arachidonic acid to prostanoids and mediators of inflammation, was investigated in the brain of simian immunodeficiency virus (SIV)-infected rhesus macaques. COX-1 and COX-2 were constitutively expressed in hippocampal and cortical neurons. COX-1 was additionally found to be expressed in cholinergic basal forebrain ne…

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C Depboylu, M Bette, D Rausch, E Weihe, L.E Eiden (2008) Expression and regulation of the two cyclooxygenase isoforms in rhesus macaque brain during lentivirus infection: differentiation of reversible inflammatory and irreversible neuronal sequelae. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086901

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