CareLit · DOI-Nachweis · Aktuelle Neurologie
Combination of hyperbaric oxygenation and selective JNK-inhibition by D-JNK-I-1 as a potent neuroprotective strategy in a focal ischaemia/reperfusion injury model in rats
DOI 10.1055/s-0028-1086927
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Herdegen, J Liu, Y Zhao, G Deuschl, C.C Eschenfelder
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: In pervious studies, hyperbaric oxygenation (HBO) was proven as a potent neuroprotective treatment in animal models of acute stroke by reducing apoptotic cell death. Furthermore, c-Jun N-terminal kinase (JNK) is activated in ischaemic neurons downstream of the activated glutamate receptors and thus mediating neuronal cell death. The highly specific peptide JNK-inhibitor D-JNK-I-1 (XG-102) has been shown…
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Zitierempfehlung
T Herdegen, J Liu, Y Zhao, G Deuschl, C.C Eschenfelder (2008) Combination of hyperbaric oxygenation and selective JNK-inhibition by D-JNK-I-1 as a potent neuroprotective strategy in a focal ischaemia/reperfusion injury model in rats. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1086927
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