CareLit · DOI-Nachweis · Aktuelle Neurologie
Mitochondria-associated apoptosis in the pathogenesis of SCA3
DOI 10.1055/s-0028-1087006
Bibliografische Angaben
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Autor:innenJ Hübener, H Wolburg, Y Ye, F Gellerich, T Schmidt, H Nguyen, O Riess
ZeitschriftAktuelle Neurologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Machado-Joseph disease (MJD) or Spinocerebellar Ataxia Type 3 (SCA3) is the most common type of SCA worldwide. SCA3 is an autosomal dominant neurodegenerative disorder caused by polyglutamine-expanded ataxin-3, whose function is still unknown. To better understand the function of Ataxin-3 in vivo, we analysed Ataxin-3 mutant mice generated by the gene trap (GT) approach. The genetrap model harboured a truncated atax…
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Zitierempfehlung
J Hübener, H Wolburg, Y Ye, F Gellerich, T Schmidt, H Nguyen, O Riess (2008) Mitochondria-associated apoptosis in the pathogenesis of SCA3. Aktuelle Neurologie (09). https://doi.org/10.1055/s-0028-1087006
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