CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
The effect of the Aurora-kinase inhibitor AZD1152-HQPA on primary ovarian cancer cell culture specimens
DOI 10.1055/s-0028-1088845
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Schem, CB Maas, K Bräutigam, DO Bauerschlag, N Arnold, J Weimer
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objective: Aurora kinases (Aurk) are involved in organizing the mitotic spindle apparatus, monitoring the correct chromosome segregation and are required for the process of cytokinesis. In many cancer entities including breast and ovarian cancer, AurkA and AurkB are overexpressed. AZD1152-HQPA is an aurora kinase inhibitor with enhanced selectivity for aurora B, causing a failure of chromosome segregation, followed…
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Zitierempfehlung
C Schem, CB Maas, K Bräutigam, DO Bauerschlag, N Arnold, J Weimer (2008) The effect of the Aurora-kinase inhibitor AZD1152-HQPA on primary ovarian cancer cell culture specimens. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0028-1088845
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