CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Acquired resistance to SAHA is MDR-independent and correlates with losses of histone acetylation, cell cycle arrest and apoptosis
DOI 10.1055/s-0028-1089156
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Fedier, KJ Dedes, P Imesch, D Fink
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Histone deacetylase inhibitors (HDACi) such as SAHA (suberoylanilide hydroxamic acid) act epigenetically by regulating gene expression through chromatin remodeling. The antineoplastic activity of HDACi is an unquestionable property HDACi. But recent studies have revealed another aspect of HDACi: their association with drug resistance. In particular, resistance acquisition during chemotherapy is a frequent obstacle i…
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Zitierempfehlung
A Fedier, KJ Dedes, P Imesch, D Fink (2008) Acquired resistance to SAHA is MDR-independent and correlates with losses of histone acetylation, cell cycle arrest and apoptosis. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0028-1089156
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