CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
A novel experimental model for investigating the molecular causes of congenital birth defects in diabetic pregnancy
DOI 10.1055/s-0028-1089272
Bibliografische Angaben
Nachweis in CareLit
Autor:innenSG Woodruff, M Loeken, K Kapelle, C Bartz, B Lüscher, W Rath
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction The offspring of women with diabetes mellitus are at increased risk for both neural tube defects (NTD) and congenital heart defects (CHD). Interestingly, hyperglycaemia-induced oxidative stress represses embryonal transcription of Pax3, a primary lineage-control gene required for neural tube closure and formation of neural crest-derived cardiac outflow tracts. Impaired expression of Pax3 during embryoni…
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Zitierempfehlung
SG Woodruff, M Loeken, K Kapelle, C Bartz, B Lüscher, W Rath (2008) A novel experimental model for investigating the molecular causes of congenital birth defects in diabetic pregnancy. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0028-1089272
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