CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor (CTGF/CCN2) expression in hepatocytes via PPARγ and Smad2/3-dependent pathways
DOI 10.1055/s-0028-1089354
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Nachweis in CareLit
Autor:innenOA Gressner, B Lahme, M Siluschek, K Rehbein, R Weiskirchen, AM Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Several epidemiological studies suggest that coffee drinking is an environmental risk modulator of hepatic fibrogenesis. Methods: We investigated the molecular events involved in caffeine-induced inhibition of TGF-β dependent and independent CTGF-expression in primary rat hepatocytes by western-blot, co-immunoprecipitations, luminometric- and reporter-gene-assays and ELISA. Results: We demonstrate that…
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Zitierempfehlung
OA Gressner, B Lahme, M Siluschek, K Rehbein, R Weiskirchen, AM Gressner (2008) Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor (CTGF/CCN2) expression in hepatocytes via PPARγ and Smad2/3-dependent pathways. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089354
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