CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
First evidence for strong epistasis between two Crohn's disease susceptibility loci: PTGER4-expression-modulating polymorphisms in the 5p13.1 region enhance ATG16L1-associated susceptibility to Crohn's disease
DOI 10.1055/s-0028-1089398
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Nachweis in CareLit
Autor:innenJ Seiderer, J Glas, G Pasciuto, J Diegelmann, C Tillack, S Pfennig, D Roeske, M Wetzke, M Jürgens, HP Török, T Griga, U Schiemann, W Klein, JT Epplen, T Mussack, P Lohse, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aims: Recently, genome-wide association studies identified a number of novel susceptibility loci for Crohn's disease (CD) including a 250 kb region on chromosome 5p13.1, which modulates PTGER4 expression (PLoS Genet 2007;3:e58). We aimed to replicate this association in a large German cohort of patients with inflammatory bowel disease (IBD) and to elucidate potential genotypic and phenotypic interacti…
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Zitierempfehlung
J Seiderer, J Glas, G Pasciuto, J Diegelmann, C Tillack, S Pfennig, D Roeske, M Wetzke, M Jürgens, HP Török, T Griga, U Schiemann, W Klein, JT Epplen, T Mussack, P Lohse, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand (2008) First evidence for strong epistasis between two Crohn's disease susceptibility loci: PTGER4-expression-modulating polymorphisms in the 5p13.1 region enhance ATG16L1-associated susceptibility to Crohn's disease. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089398
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