CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Bortezomib modulates Toll-like receptor mediated activation of non-parenchymal liver cells and has antiviral activity on HCV replication
DOI 10.1055/s-0028-1089427
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJP Sowa, A Bucci, JF Schlaak, G Gerken
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The proteasome inhibitor Bortezomib is used in the treatment of multiple myeloma. Since the proteasome plays a role in TLR-pathways we hypothesized that Bortezomib could also influence TLR mediated activation of non-parenchymal liver cells (NPC) which could be relevant for inflammatory processes in the liver. Methods: Kupffer cells (KC) and LSECs were isolated from CL57/BL mice. Cells were stimulated with TLR3…
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Zitierempfehlung
JP Sowa, A Bucci, JF Schlaak, G Gerken (2008) Bortezomib modulates Toll-like receptor mediated activation of non-parenchymal liver cells and has antiviral activity on HCV replication. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089427
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