CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
UDCA targets S-phase and suppresses CDK2 and cyclin A expression: effects on colon cancer cell proliferation
DOI 10.1055/s-0028-1089496
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Autor:innenR Peiro-Jordan, S Subramanian, ML Hanski, J Behrens, M Zeitz, C Hanski
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Ursodeoxycholic acid (UDCA) treatment of patients with primary sclerosing cholangitis appears to reduce the risk of colon cancer. UDCA prevents colon cancer in animal models; the mechanism of the chemopreventive action is still unknown. We investigated the effects of UDCA on proliferation of colon cancer cells in vitro. Methods: Six established human carcinoma cell lines were treated with UDCA (0–400µM…
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Zitierempfehlung
R Peiro-Jordan, S Subramanian, ML Hanski, J Behrens, M Zeitz, C Hanski (2008) UDCA targets S-phase and suppresses CDK2 and cyclin A expression: effects on colon cancer cell proliferation. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089496
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