CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Pancreas-specific ablation of Notch2 but not Notch1 compromises KrasG12D-induced PanIN progression and tumor development
DOI 10.1055/s-0028-1089536
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Nachweis in CareLit
Autor:innenJT Siveke, P Mazur, B Sipos, H Nakhai, F Radtke, L Strobl, U Zimber-Strobl, G Klöppel, RM Schmid
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Notch signaling has been implicated in stem/progenitor cell regulation and is known to play an important role in tumor development including pancreatic carcinogenesis. In this study we analyzed the effect of pancreas-specific Notch receptor ablation in addition to mutant KrasG12D activation in an endogenous gene-targeted mouse model of pancreatic cancer, which recapitulates the full spectrum of the human disease inc…
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Zitierempfehlung
JT Siveke, P Mazur, B Sipos, H Nakhai, F Radtke, L Strobl, U Zimber-Strobl, G Klöppel, RM Schmid (2008) Pancreas-specific ablation of Notch2 but not Notch1 compromises KrasG12D-induced PanIN progression and tumor development. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089536
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