CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Selective influence of Tcf-1 and Tcf-4 mediated WNT signaling on intestinal innate immunity of ileal Crohn's disease
DOI 10.1055/s-0028-1089571
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Nachweis in CareLit
Autor:innenM Koslowski, G Wang, I Kübler, K Fellermann, E Stange, J Wehkamp
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Ileal Crohn's disease (CD) is characterized by diminished antibacterial activity and a specific decrease of small intestinal Paneth cell α-defensins HD5 and 6. We previously reported a causal link between this decrease and the Wnt pathway transcription factor Tcf-4. Wnt signaling has an important function in intestinal epithelium renewal, regulating stem cell maintenance and their transition to Paneth-cells. T…
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Zitierempfehlung
M Koslowski, G Wang, I Kübler, K Fellermann, E Stange, J Wehkamp (2008) Selective influence of Tcf-1 and Tcf-4 mediated WNT signaling on intestinal innate immunity of ileal Crohn's disease. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089571
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