CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Influence of inflammation and treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease
DOI 10.1055/s-0028-1089573
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Autor:innenI Kübler, M Gersemann, K Fellermann, M Koslowski, G Wang, KR Herrlinger, EF Stange, J Wehkamp
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Crohn's Disease (CD) has been linked to different functional deficiencies of antimicrobial defensins. Ileal CD is characterized by reduced expression of α-defensins (HD5, HD6). The mechanism is a compromised WNT/Tcf4 stem cell differentiation pathway and -in some cases- a mutation in NOD2. Colonic CD is mediated by an attenuated induction of β-defensins (HBD2, HBD3) which is due to a gene copy number polymorph…
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Zitierempfehlung
I Kübler, M Gersemann, K Fellermann, M Koslowski, G Wang, KR Herrlinger, EF Stange, J Wehkamp (2008) Influence of inflammation and treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089573
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