CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Epistasis between Toll-like receptor (TLR)-9 polymorphisms and variants in IL23R and DLG5 modulates susceptibility to Crohn's disease
DOI 10.1055/s-0028-1089588
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Nachweis in CareLit
Autor:innenHP Török, J Glas, J Konnerth, M Wetzke, P Lohse, T Ochsenkühn, M Folwaczny, B Göke, C Folwaczny, B Müller-Myhsok, S Brand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The identification of NOD2 provides important genetic evidence for the role of innate pattern recognition receptors in the pathogenesis of Crohn's disease (CD). Recognition of bacterial DNA via TLR9 seems to be crucial for the maintenance of gut homeostasis and gut inflammation. We previously showed that a promoter polymorphism in TLR9 (-1237 T/C) further increases disease risk in CD patients bearing NOD2 muta…
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Zitierempfehlung
HP Török, J Glas, J Konnerth, M Wetzke, P Lohse, T Ochsenkühn, M Folwaczny, B Göke, C Folwaczny, B Müller-Myhsok, S Brand (2008) Epistasis between Toll-like receptor (TLR)-9 polymorphisms and variants in IL23R and DLG5 modulates susceptibility to Crohn's disease. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089588
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