CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Auto-regulation of human Tcf-4 by Wnt-β-catenin-Tcf-4 signaling
DOI 10.1055/s-0028-1089651
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Autor:innenG Wang, O Burk, E Stange, J Wehkamp
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Tcf-4 is a major transcription factor in the Wnt/β-catenin pathway. Wnt signaling plays a critical role in stem cell maintenance and Paneth cell differentiation in intestinal crypts abd over-activation is thought to be important in intestinal carcinogenesis. We recently reported a reduced expression of Tcf-4 in ileal Crohn's disease (CD) leading to reduced expression of Paneth cell α-defensins. This link provi…
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Zitierempfehlung
G Wang, O Burk, E Stange, J Wehkamp (2008) Auto-regulation of human Tcf-4 by Wnt-β-catenin-Tcf-4 signaling. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089651
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