CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The oncolytic adenovirus Ad-iREP-2 utilizes p53-dependent rna interference for tumor-selective replication
DOI 10.1055/s-0028-1089670
Bibliografische Angaben
Nachweis in CareLit
Autor:innenE Gürlevik, P Schache, L Zender, MP Manns, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Inactivation of p53-transcriptional activity is a crucial step of tumorigenesis and occurs in the majority of human cancers. Consequently, transcriptional p53-deficiency represents an excellent broad-range target for tailored therapies. We have developed the oncolytic adenovirus Ad-iREP-2 for selective replication in tumor cells without functional p53. To control its replication, Ad-iREP-2 contains an RNAi network,…
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Zitierempfehlung
E Gürlevik, P Schache, L Zender, MP Manns, S Kubicka, F Kühnel (2008) The oncolytic adenovirus Ad-iREP-2 utilizes p53-dependent rna interference for tumor-selective replication. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089670
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