CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Generation of a conditionally replicating adenovirus harboring a p53-dependent self-destruction switch for treatment of p53-altered tumors
DOI 10.1055/s-0028-1089674
Bibliografische Angaben
Nachweis in CareLit
Autor:innenP Schache, E Gürlevik, N Strüver, MP Manns, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Conditionally replicating adenoviruses represent a promising approach for the treatment of solid tumors. Actual concepts focus on restricting viral replication to malignant cells but no concepts exist that selectively target the vector DNA for destructions in normal cells. In this study we present conditioned oncolytic adenoviruses harboring a nuclease function for seIective vector destruction in p53-normal cells. W…
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Zitierempfehlung
P Schache, E Gürlevik, N Strüver, MP Manns, S Kubicka, F Kühnel (2008) Generation of a conditionally replicating adenovirus harboring a p53-dependent self-destruction switch for treatment of p53-altered tumors. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0028-1089674
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