CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
TGF-beta alters liver regeneration and ductular reaction via Notch signaling, thus contributing to HBV-associated fibrogenesis
DOI 10.1055/s-0029-1191753
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Nachweis in CareLit
Autor:innenH Weng, L Ciuclan, C Meyer, T Huang, PR Mertens, MV Singer, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hepatic progenitor cells (HPC) instead of normal hepatocytes become the main population of regenerative hepatocytes, promoting a periportal ductular reaction (DR), which may contribute to periportal fibrogenesis in chronic liver disease in association with HCV and NASH. We hypothesize that a TGF-b-Notch signaling dependent alteration of the replicative pathway of hepatocytes and a subsequent DR play a critical role…
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Zitierempfehlung
H Weng, L Ciuclan, C Meyer, T Huang, PR Mertens, MV Singer, S Dooley (2009) TGF-beta alters liver regeneration and ductular reaction via Notch signaling, thus contributing to HBV-associated fibrogenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191753
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