CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid de-differentiation and TGF-β induced apoptosis
DOI 10.1055/s-0029-1191766
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Autor:innenP Godoy, JG Hengstler, I Ilkavets, C Meyer, A Bachmann, A Müller, G Tuschl, SO Müller, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the response of the liver to cytokines. However, it is well established that hepatocytes cultured on monolayers of monomeric collagen dedifferentiate, loosing specialized liver functions. Here we report that hepatocyte dedifferentiation is a reversible consequence of a specific signaling network constellation triggered by the extracellu…
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Zitierempfehlung
P Godoy, JG Hengstler, I Ilkavets, C Meyer, A Bachmann, A Müller, G Tuschl, SO Müller, S Dooley (2009) Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid de-differentiation and TGF-β induced apoptosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191766
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