CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells
DOI 10.1055/s-0029-1191768
Bibliografische Angaben
Nachweis in CareLit
Autor:innenOA Gressner, B Lahme, K Rehbein, M Siluschek, R Weiskirchen, AM Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Recently, we identified hepatocytes as the major cellular source of profibrogenic connective tissue growth factor (CTGF/CCN2) in the liver. Based on reports of a hepatoprotective effect of coffee consumption, we were the first to give evidence that caffeine suppresses TGF-β dependent and -independent CTGF expression in hepatocytes, thus suggesting this xanthine-alkaloid as a potentially therapeutic agent. Aim:…
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Zitierempfehlung
OA Gressner, B Lahme, K Rehbein, M Siluschek, R Weiskirchen, AM Gressner (2009) Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191768
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