CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Impaired hepatocyte priming contributes to dysregulated proliferation and leads to death during liver regeneration in conditional NEMO ko mice
DOI 10.1055/s-0029-1191786
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Nachweis in CareLit
Autor:innenY Malato, N Beraza, M Al-Masaoudi, C Liedtke, C Trautwein
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
IKKγ/NEMO is the regulatory subunit of the IKK complex activating the transcription factor NF-κB. Hepatocyte-specific NEMO knock-out (ko) animals show a complete inhibition of NF-κB signalling in parenchymal cells leading to a severe phenotype. The animals develop spontaneous hepatocyte apoptosis counterbalanced by proliferation, progressing to hepatocellular carcinoma. As NF-κB is involved in early events of hepato…
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Zitierempfehlung
Y Malato, N Beraza, M Al-Masaoudi, C Liedtke, C Trautwein (2009) Impaired hepatocyte priming contributes to dysregulated proliferation and leads to death during liver regeneration in conditional NEMO ko mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191786
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