CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
TGF-β1 mediated Smad1/Smad5 signalling modulates transdifferentiation of hepatic stellate cells
DOI 10.1055/s-0029-1191787
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Autor:innenSK Meurer, L Tihaa, R Weiskirchen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: The main cellular source of extracellular matrix (ECM) in the fibrotic liver are myofibroblast like cells (MFB). MFB originate from activated hepatic stellate cells (HSC) through a process called „transdifferentiation“. Both transdifferentiation and the fibrotic response of activated HSC are regulated by TGF-β1/ALK5/Smad3 signalling. In addition an involvement of TGF-β1/ALK1/Smad1 in these processes has been p…
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Zitierempfehlung
SK Meurer, L Tihaa, R Weiskirchen (2009) TGF-β1 mediated Smad1/Smad5 signalling modulates transdifferentiation of hepatic stellate cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191787
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