CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
TGF-β1 initiates signaling from the plasma membrane in hepatocytes
DOI 10.1055/s-0029-1191788
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Autor:innenC Meyer, P Godoy, A Bachmann, A Müller, C Stump, I Ilkavets, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The role of endocytosis in TGF-β1 signaling is controversially discussed. Two TGF-β-receptor internalization routes have been proposed. A clathrin mediated uptake resulting in Smad phosphorylation, translocation to the nucleus and transcriptional activity. Via this route, receptors can be recycled back to the cell surface in a Rab11 dependent manner, whereas the caveolin dependent internalization leads to TGF-β1 sig…
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Zitierempfehlung
C Meyer, P Godoy, A Bachmann, A Müller, C Stump, I Ilkavets, S Dooley (2009) TGF-β1 initiates signaling from the plasma membrane in hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191788
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