CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Fatty Acid Amide Hydrolase but not Monoacyl Glycerol Lipase Is a Crucial Determinant of Endocannabinoid-induced Cell Death in Hepatic Cell Populations
DOI 10.1055/s-0029-1191800
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Autor:innenSV Siegmund, A Wojtalla, F Herweck, MV Singer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: We have shown that the endcannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) selectively induce cell death in activated hepatic stellate cells (HSCs), but not in hepatocytes. In contrast to HSCs, hepatocytes highly express the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) that protects them from AEA-induced injury. However, the hepatic expression pattern and function of the 2-AG-de…
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Zitierempfehlung
SV Siegmund, A Wojtalla, F Herweck, MV Singer (2009) Fatty Acid Amide Hydrolase but not Monoacyl Glycerol Lipase Is a Crucial Determinant of Endocannabinoid-induced Cell Death in Hepatic Cell Populations. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191800
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