CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Bile acid-induced EGFR activation in quiescent hepatic stellate cells can trigger both, proliferation and apoptosis
DOI 10.1055/s-0029-1191801
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Autor:innenA Sommerfeld, D Häussinger, R Reinehr
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Quiescent HSC are fairly resistant to CD95-mediated apoptosis and CD95L [1] as well as hydrophobic bile acids [2] have been shown to activate EGFR in those cells. In addition, qHSC express CD133 and might represent a hepatic stem/progenitor cell compartment [3]. Rat HSC were cultured for 1–2 days. Activation of EGFR, Src and MAP kinases was measured by W.blot. CD95 was immunoprecipitated and detected for EGFR-associ…
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Zitierempfehlung
A Sommerfeld, D Häussinger, R Reinehr (2009) Bile acid-induced EGFR activation in quiescent hepatic stellate cells can trigger both, proliferation and apoptosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191801
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