CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The regulation of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 by 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is altered by a functional promoter variant
DOI 10.1055/s-0029-1191818
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Autor:innenU Ehmer, S Kalthoff, T Erichsen, N Freiberg, MP Manns, CP Strassburg
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The UGT-Glucuronosyltransferase (UGT) 1A7 plays an important role in the metabolism of endogenous and xenobiotic substrates, which include environmental carcinogens and drugs such as the chemotherapeutic compound irinotecan. Low activity alleles of UGT1A7 characterized by variations within the coding and non-coding sequence are associated with cancer predisposition and drug toxicity. The transcriptiona…
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Zitierempfehlung
U Ehmer, S Kalthoff, T Erichsen, N Freiberg, MP Manns, CP Strassburg (2009) The regulation of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 by 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is altered by a functional promoter variant. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191818
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