CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatocyte-specific deficiency of SOD-2 causes liver failure and promotes tumorigenesis
DOI 10.1055/s-0029-1191830
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Autor:innenM Jakupovic, F Dombrowski, T Kietzmann
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In the mitochondrial matrix manganese superoxide dismutase (SOD-2) is the essential antioxidant enzyme that degrades reactive oxygen species. The liver has the highest specific MnSOD activity, which implies its important role for maintaining proper organ function and to prevent pathological situations such as cancer. In line with this, we generated hepatocyte-specific SOD-2 knockout mice and found that that ROS leve…
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Zitierempfehlung
M Jakupovic, F Dombrowski, T Kietzmann (2009) Hepatocyte-specific deficiency of SOD-2 causes liver failure and promotes tumorigenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191830
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