CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Chronic Alcohol Feeding Stimulates the Formation of Mutagenic Etheno-Adducts in a Rodent model of NASH Via Induction of Cytochrome P450 2E1
DOI 10.1055/s-0029-1191847
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Autor:innenF Stickel, E Patsenker, Y Wang, V Schneider, M Ledermann, H Saegesser, S Mueller, HK Seitz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background and Aims: Chronic alcohol consumption may cause liver fibrosis and hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD). Synergistic effects of insulin resistance and alcohol triggering fibrogenesis and HCC are implicated. Formation of mutagenic etheno adducts binding to adenosin (EdA) generated via induced CYP2E1 has been suggested as a key mechanisms of hepatocarcinogenesis. Metho…
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Zitierempfehlung
F Stickel, E Patsenker, Y Wang, V Schneider, M Ledermann, H Saegesser, S Mueller, HK Seitz (2009) Chronic Alcohol Feeding Stimulates the Formation of Mutagenic Etheno-Adducts in a Rodent model of NASH Via Induction of Cytochrome P450 2E1. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191847
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