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Superiority of flavonol 2,3-dehydrosilybin than its parental silybin in inhibiting DNA topoisomerase I: An anti-cancer mechanism of 2,3-dehydrosilybin

W Chamulitrat, P Thongphasuk, W Stremmel · Zeitschrift für Gastroenterologie · Ausgabe 01/2009

DOI 10.1055/s-0029-1191866

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Autor:innenW Chamulitrat, P Thongphasuk, W Stremmel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Antioxidant silybin is the major compound found in silymarin extracts which have been used to treat liver diseases for several decades. Silybin is now being tested in clinical trials to treat prostate and breast cancers. We have previously reported that the oxidized form of silybin so-called 2,3-dehydrosilybin (DHS) exhibits more potent antioxidant activities than silybin by three folds in in vitro and in vivo syste…

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W Chamulitrat, P Thongphasuk, W Stremmel (2009) Superiority of flavonol 2,3-dehydrosilybin than its parental silybin in inhibiting DNA topoisomerase I: An anti-cancer mechanism of 2,3-dehydrosilybin. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191866

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