CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The novel histonedeacetylase inhibitor Panobinostat induces alternative pathways of apoptosis in hepatocellular carcinoma models
DOI 10.1055/s-0029-1191868
Bibliografische Angaben
Nachweis in CareLit
Autor:innenP Di Fazio, R Schneider-Stock, T Wissniowski, S Gahr, D Neureiter, M Ocker
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Inhibitors of histone deacetylases (HDACi) represent a novel therapeutic option for human cancer diseases. The novel pan-HDACi Panobinostat (LBH589) induces apoptosis in human hepatocellular tumor cells in vitro and in xenograft models in vivo. Here, we analysed the underlying signalling pathways in more detail. Methods: Human hepatocellular carcinoma (HCC) cell lines HepG2 (p53wt) and Hep3b (p53null) were cul…
Zitieren
Zitierempfehlung
P Di Fazio, R Schneider-Stock, T Wissniowski, S Gahr, D Neureiter, M Ocker (2009) The novel histonedeacetylase inhibitor Panobinostat induces alternative pathways of apoptosis in hepatocellular carcinoma models. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191868
Mit CareLit weiterarbeiten