CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
VSV virotherapy of tumors enhances chemotherapeutic efficacy by proteasomal degradation of MCL-1
DOI 10.1055/s-0029-1191898
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Autor:innenP Schache, N Strüver, E Gürlevik, MP Manns, F Kühnel, S Kubicka
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Over-expression of myeloid cell leukemia 1 protein (Mcl-1), an anti-apoptotic Bcl-2 family member, contributes to chemotherapy resistance of tumors. The short half-life of Mcl-1 makes it an interesting target for therapeutic agents that negatively interfere with cellular protein biosynthesis such as oncolytic viruses (Wirth et al. 2005). Vesicular stomatitis virus (VSV) has been established as oncolytic virus that e…
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Zitierempfehlung
P Schache, N Strüver, E Gürlevik, MP Manns, F Kühnel, S Kubicka (2009) VSV virotherapy of tumors enhances chemotherapeutic efficacy by proteasomal degradation of MCL-1. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191898
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