CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Generation of a conditionally replicating adenovirus harboring a P53-dependent self-destruction switch for treatment of P53-altered tumors
DOI 10.1055/s-0029-1191899
Bibliografische Angaben
Nachweis in CareLit
Autor:innenP Schache, A Goez, E Gürlevik, N Strüver, MP Manns, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background/aims: Conditionally replicating adenoviruses represent a promising approach for the treatment of solid tumors. Actual concepts focus on restricting viral replication to malignant cells but no concept exists that targets the viral vector DNA itself for selective destruction in normal cells. Here, we present an p53-dependent oncolytic adenovirus harboring a nuclease function for selective vector destruction…
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Zitierempfehlung
P Schache, A Goez, E Gürlevik, N Strüver, MP Manns, S Kubicka, F Kühnel (2009) Generation of a conditionally replicating adenovirus harboring a P53-dependent self-destruction switch for treatment of P53-altered tumors. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191899
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