CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma (HCC)
DOI 10.1055/s-0029-1191901
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Autor:innenAE Schulze Schleithoff, A Kairat, AF Koch, K Lorenz, W Stremmel, M Müller
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Whereas the hallmark of wild-type (wt) p53 is its tumor suppressor activity, tumor-associated mutant p53 proteins can exert novel antiapoptotic gain of function activities, which confer a selective advantage upon tumor cells harboring such mutations. The p53 family members p63 and p73 give raise to proteins that have p53-agonistic as well as p53-antagonistic functions. p63 and p73 express two main clas…
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Zitierempfehlung
AE Schulze Schleithoff, A Kairat, AF Koch, K Lorenz, W Stremmel, M Müller (2009) Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma (HCC). Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191901
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