CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A new animal model of chronic autoimmune hepatitis mediated by the adaptive immune system
DOI 10.1055/s-0029-1191931
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Fischer, M Hardtke-Wolenski, MP Manns, E Jaeckel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Progress in our understanding of autoimmune hepatitis (AIH) has been hampered by the lack of suitable animal models. Here we developed a strategy to break tolerance of a negatively selected, wild-type T cell repertoire by combining a self limited infection providing a danger signal together with modified liver self-antigens into mice. To this end we generated replication-deficient adenoviral constructs expressing co…
Zitieren
Zitierempfehlung
K Fischer, M Hardtke-Wolenski, MP Manns, E Jaeckel (2009) A new animal model of chronic autoimmune hepatitis mediated by the adaptive immune system. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191931
Mit CareLit weiterarbeiten