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Modulation of the longevity proteins FOXO3a and SIRT1 by chorionic gonadotropin prevents hepatocellular injury during acute liver inflammation

C Steinmetz, S Jin, S Rühl, H Schulze-Bergkamen, J Lotz, J Kuball, M Theobald, G Otto, PR Galle, D Strand, S Strand · Zeitschrift für Gastroenterologie · Ausgabe 01/2009

DOI 10.1055/s-0029-1191954

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Autor:innenC Steinmetz, S Jin, S Rühl, H Schulze-Bergkamen, J Lotz, J Kuball, M Theobald, G Otto, PR Galle, D Strand, S Strand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2009
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

During pregnancy, the clinical improvement of autoimmune hepatitis is frequently observed. The understanding of this phenomenon is incomplete both from the side of the immune system and the liver. Using a murine model of autoimmune hepatitis and adult human hepatocytes in primary culture, we could show that the pregnancy hormone, human chorionic gonadotropin (hCG) regulates the longevity proteins FOXO3a and SIRT1, w…

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C Steinmetz, S Jin, S Rühl, H Schulze-Bergkamen, J Lotz, J Kuball, M Theobald, G Otto, PR Galle, D Strand, S Strand (2009) Modulation of the longevity proteins FOXO3a and SIRT1 by chorionic gonadotropin prevents hepatocellular injury during acute liver inflammation. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1191954

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