Pre-eclampsia – from Placenta to General Disease

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Pre-eclampsia is recognised clinically by its affects on the mother and baby in the second half of pregnancy, but most cases have their origin much earlier. The primary problem lies in the development of the placenta and its blood supply and is believed to have an immunological cause. In particular, it involves the interaction of a unique pattern of Class I MHC molecules (HLA-C, HLA-G, HLA-E) expressed by the invasi…

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