CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Individual stearoyl-CoA desaturase 1 (SCD1) expression modulates ER stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
DOI 10.1055/s-0029-1221993
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Nachweis in CareLit
Autor:innenA Peter, C Weigert, H Staiger, F Machicao, F Schick, J Machann, N Stefan, C Thamer, HU Häring, E Schleicher
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Objective: Increased plasma levels of free fatty acids occur in obesity and type 2 diabetes and contribute to the development of insulin resistance. Especially saturated fatty acids (SFA) like palmitate have lipotoxic effects leading to endoplasmatic-reticulum (ER) stress, inflammation and insulin resistance. Stearoyl-CoA desaturase 1 (SCD1) plays a key role in preventing lipotoxic effects as it converts SFA to less…
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Zitierempfehlung
A Peter, C Weigert, H Staiger, F Machicao, F Schick, J Machann, N Stefan, C Thamer, HU Häring, E Schleicher (2009) Individual stearoyl-CoA desaturase 1 (SCD1) expression modulates ER stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0029-1221993
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