CareLit · DOI-Nachweis · Klinische Pädiatrie
The human AF4 and AF4·MLL multiprotein complexes provide functions in transcription and epigenetic processes
DOI 10.1055/s-0029-1222624
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Benedikt, S Baltruschat, TN Arrey, B Meyer, M Karas, A Bursen, T Dingermann, R Marschalek
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The most frequent MLL translocation is the chromosomal translocation t(4;11)(q21;q23) that is predominantly associated with a high-risk ALL disease phenotype in infant, childhood and adult leukemia patients. Previous investigations have revealed oncogenic properties of overexpressed AF4 and AF4·MLL in mammalian cells, while the AF4·MLL fusion protein was capable to initiate and maintain leukemogenic transformation w…
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Zitierempfehlung
A Benedikt, S Baltruschat, TN Arrey, B Meyer, M Karas, A Bursen, T Dingermann, R Marschalek (2009) The human AF4 and AF4·MLL multiprotein complexes provide functions in transcription and epigenetic processes. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222624
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